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mea maestro edge system  (Axion BioSystems)

 
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    Axion BioSystems mea maestro edge system
    Mea Maestro Edge System, supplied by Axion BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mea maestro edge system/product/Axion BioSystems
    Average 90 stars, based on 1 article reviews
    mea maestro edge system - by Bioz Stars, 2026-06
    90/100 stars

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    Restoration of synchrony loss in primary neurons from αSyn transgenic mice upon SNX5 knockdown. a Experimental timeline of primary neuron <t>isolation,</t> <t>maturation</t> and siPOOL application in vitro; DIV, days in vitro. b Quantification of SNX5 mRNA expression in primary neurons from the transgenic Thy1-αSyn (Line 61) mouse model. The cells were transfected with siPOOL siRNAs against SNX5 or a negative control siRNA, or untransfected. c Multiwell microelectrode array <t>(MEA)</t> measurement of neuronal synchrony at 18 h after application of DMSO (left side bars) or 50 µmol/L bafilomycin A1 in DMSO of the same conditions as described in panel b . The graph shows results from 1 out of 3 representative technical replicates; bars represent mean ± SEM; n.s. = not significant, * P < 0.05; Two-way ANOVA with Sidak’s post-hoc test
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    Restoration of synchrony loss in primary neurons from αSyn transgenic mice upon SNX5 knockdown. a Experimental timeline of primary neuron <t>isolation,</t> <t>maturation</t> and siPOOL application in vitro; DIV, days in vitro. b Quantification of SNX5 mRNA expression in primary neurons from the transgenic Thy1-αSyn (Line 61) mouse model. The cells were transfected with siPOOL siRNAs against SNX5 or a negative control siRNA, or untransfected. c Multiwell microelectrode array <t>(MEA)</t> measurement of neuronal synchrony at 18 h after application of DMSO (left side bars) or 50 µmol/L bafilomycin A1 in DMSO of the same conditions as described in panel b . The graph shows results from 1 out of 3 representative technical replicates; bars represent mean ± SEM; n.s. = not significant, * P < 0.05; Two-way ANOVA with Sidak’s post-hoc test
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    Restoration of synchrony loss in primary neurons from αSyn transgenic mice upon SNX5 knockdown. a Experimental timeline of primary neuron <t>isolation,</t> <t>maturation</t> and siPOOL application in vitro; DIV, days in vitro. b Quantification of SNX5 mRNA expression in primary neurons from the transgenic Thy1-αSyn (Line 61) mouse model. The cells were transfected with siPOOL siRNAs against SNX5 or a negative control siRNA, or untransfected. c Multiwell microelectrode array <t>(MEA)</t> measurement of neuronal synchrony at 18 h after application of DMSO (left side bars) or 50 µmol/L bafilomycin A1 in DMSO of the same conditions as described in panel b . The graph shows results from 1 out of 3 representative technical replicates; bars represent mean ± SEM; n.s. = not significant, * P < 0.05; Two-way ANOVA with Sidak’s post-hoc test
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    Restoration of synchrony loss in primary neurons from αSyn transgenic mice upon SNX5 knockdown. a Experimental timeline of primary neuron isolation, maturation and siPOOL application in vitro; DIV, days in vitro. b Quantification of SNX5 mRNA expression in primary neurons from the transgenic Thy1-αSyn (Line 61) mouse model. The cells were transfected with siPOOL siRNAs against SNX5 or a negative control siRNA, or untransfected. c Multiwell microelectrode array (MEA) measurement of neuronal synchrony at 18 h after application of DMSO (left side bars) or 50 µmol/L bafilomycin A1 in DMSO of the same conditions as described in panel b . The graph shows results from 1 out of 3 representative technical replicates; bars represent mean ± SEM; n.s. = not significant, * P < 0.05; Two-way ANOVA with Sidak’s post-hoc test

    Journal: Translational Neurodegeneration

    Article Title: A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson’s disease cell model

    doi: 10.1186/s40035-025-00486-5

    Figure Lengend Snippet: Restoration of synchrony loss in primary neurons from αSyn transgenic mice upon SNX5 knockdown. a Experimental timeline of primary neuron isolation, maturation and siPOOL application in vitro; DIV, days in vitro. b Quantification of SNX5 mRNA expression in primary neurons from the transgenic Thy1-αSyn (Line 61) mouse model. The cells were transfected with siPOOL siRNAs against SNX5 or a negative control siRNA, or untransfected. c Multiwell microelectrode array (MEA) measurement of neuronal synchrony at 18 h after application of DMSO (left side bars) or 50 µmol/L bafilomycin A1 in DMSO of the same conditions as described in panel b . The graph shows results from 1 out of 3 representative technical replicates; bars represent mean ± SEM; n.s. = not significant, * P < 0.05; Two-way ANOVA with Sidak’s post-hoc test

    Article Snippet: The plates were transferred daily into the Maestro Edge MEA system (Axion Biosystems) for evaluation of cellular functions during maturation.

    Techniques: Transgenic Assay, Knockdown, Isolation, In Vitro, Expressing, Transfection, Negative Control, Microelectrode Array